Comb jellies reveal ancient origins of animal genome regulation
Life depends on genes being switched on and off at exactly the right time. Even the simplest living organisms do this, but usually over short distances across the DNA sequence, with the on/off switch typically right next to a gene. This basic form of genomic regulation is probably as old as life on Earth. A new study finds that the ability to control genes from far away, over many tens of thousands of DNA letters, evolved between 650 and 700 million years ago. It probably appeared at the very dawn of animal evolution, around 150 million years earlier than previously thought. The critical innovation likely originated in a sea creature, the common ancestor or all extant animals.
Life depends on genes being switched on and off at exactly the right time. Even the simplest living organisms do this, but usually over short distances across the DNA sequence, with the on/off switch typically right next to a gene. This basic form of genomic regulation is probably as old as life on Earth. A new study finds that the ability to control genes from far away, over many tens of thousands of DNA letters, evolved between 650 and 700 million years ago. It probably appeared at the very dawn of animal evolution, around 150 million years earlier than previously thought. The critical innovation likely originated in a sea creature, the common ancestor or all extant animals.
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